12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/2018 | N | 1 | Alabama | L | 14 | 51 | 0-1 | 57,280 | Orlando | Fla. | Camping World Stadium | Camping World Kickoff | |||
| 09/08/2018 | H | Indiana State | W | 31 | 7 | 1-1 | 44,520 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/15/2018 | H | Western Kentucky | W | 20 | 17 | 2-1 | 54,923 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/22/2018 | A | Virginia | L | 3 | 27 | 2-2 | 0-1 | 34,446 | Charlottesville | Va. | Scott Stadium | ||||
| 09/29/2018 | H | Florida State | L | 24 | 28 | 2-3 | 0-2 | 52,798 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/05/2018 | H | Georgia Tech | L | 31 | 66 | 2-4 | 0-3 | 51,658 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/13/2018 | A | Boston College | L | 20 | 38 | 2-5 | 0-4 | 31,478 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 10/27/2018 | H | Wake Forest | L | 35 | 56 | 2-6 | 0-5 | 49,603 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/03/2018 | A | 2 | Clemson | L | 16 | 77 | 2-7 | 0-6 | 78,741 | Clemson | S.C. | Memorial Stadium | |||
| 11/09/2018 | A | 13 | Syracuse | L | 23 | 54 | 2-8 | 0-7 | 42,797 | Syracuse | N.Y. | Carrier Dome | |||
| 11/17/2018 | H | North Carolina State | L | 10 | 52 | 2-9 | 0-8 | 48,265 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/24/2018 | H | 17 | Kentucky | L | 10 | 56 | 2-10 | 0-8 | 49,988 | Louisville | Ky. | Cardinal Stadium |