5 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/22/1921 | H | Hanover | W | 19 | 8 | 1-0 | Louisville | Ky. | Eclipse Park | ||||||
| 10/29/1921 | A | Bethel, Ky. | T | 0 | 0 | 1-0-1 | Russellville | Ky. | |||||||
| 11/05/1921 | A | Transylvania | L | 0 | 7 | 1-1-1 | Lexington | Ky. | Thomas Field | ||||||
| 11/18/1921 | H | Kentucky Wesleyan | W | 30 | 0 | 2-1-1 | Louisville | Ky. | Eclipse Park | ||||||
| 11/26/1921 | A | Marshall | L | 0 | 14 | 2-2-1 | Huntington | W.Va. | Marshall Field |