9 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/30/1922 | H | Western Kentucky | L | 0 | 6 | 0-1 | Louisville | Ky. | Eclipse Park | ||||||
| 10/07/1922 | H | Bethel, Ky. | L | 12 | 14 | 0-2 | Louisville | Ky. | Eclipse Park | ||||||
| 10/14/1922 | A | Kentucky | L | 0 | 73 | 0-3 | Lexington | Ky. | Stoll Field | ||||||
| 10/21/1922 | H | Franklin | L | 6 | 27 | 0-4 | Louisville | Ky. | Eclipse Park | ||||||
| 10/28/1922 | A | Centre | L | 7 | 32 | 0-5 | Danville | Ky. | Cheek Field | ||||||
| 11/04/1922 | H | Cincinnati JV | W | 28 | 0 | 1-5 | Louisville | Ky. | Eclipse Park | ||||||
| 11/11/1922 | A | Rose Poly | W | 6 | 0 | 2-5 | Terre Haute | Ind. | |||||||
| 11/18/1922 | H | Centenary | L | 13 | 39 | 2-6 | Louisville | Ky. | Eclipse Park | ||||||
| 11/30/1922 | A | Marshall | L | 7 | 21 | 2-7 | Huntington | W.Va. |