10 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/23/1950 | H | Saint Francis, Pa. | W | 34 | 14 | 1-0 | Louisville | Ky. | duPont Manual Stadium | ||||||
| 09/30/1950 | H | Buffalo | W | 48 | 19 | 2-0 | Louisville | Ky. | duPont Manual Stadium | ||||||
| 10/07/1950 | A | Cincinnati | L | 20 | 28 | 2-1 | 19,000 | Cincinnati | Ohio | Nippert Stadium | |||||
| 10/14/1950 | A | Houston | L | 7 | 27 | 2-2 | 5,000 | Houston | Texas | Houston Public School Stadium | |||||
| 10/21/1950 | A | Xavier | L | 13 | 36 | 2-3 | 10,000 | Cincinnati | Ohio | Xavier Stadium | |||||
| 10/28/1950 | H | Duquesne | L | 20 | 27 | 2-4 | 12,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/04/1950 | A | Washington, Mo. | W | 28 | 7 | 3-4 | 3,750 | St. Louis | Mo. | Francis Field | |||||
| 11/10/1950 | A | 9 | Miami, Fla. | T | 13 | 13 | 3-4-1 | 28,824 | Miami | Fla. | Orange Bowl | ||||
| 11/18/1950 | H | Washington & Lee | L | 28 | 33 | 3-5-1 | 10,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/25/1950 | A | Southern Mississippi | L | 28 | 34 | 3-6-1 | 6,000 | Hattiesburg | Miss. |