9 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/29/1951 | A | Wayne State | W | 28 | 12 | 1-0 | 7,500 | Detroit | Mich. | University of Detroit Stadium | |||||
| 10/05/1951 | H | Boston University | L | 7 | 39 | 1-1 | 9,750 | Louisville | Ky. | duPont Manual Stadium | |||||
| 10/13/1951 | A | Cincinnati | L | 0 | 38 | 1-2 | 16,000 | Cincinnati | Ohio | Nippert Stadium | |||||
| 10/19/1951 | H | Xavier | L | 6 | 47 | 1-3 | 6,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 10/27/1951 | A | Saint Bonaventure | L | 21 | 22 | 1-4 | Saint Bonaventure | N.Y. | |||||||
| 11/02/1951 | H | North Carolina State | W | 26 | 2 | 2-4 | 1,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/10/1951 | H | Houston | W | 35 | 28 | 3-4 | 3,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/17/1951 | H | Washington & Lee | W | 14 | 7 | 4-4 | 6,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/23/1951 | H | Southern Mississippi | W | 14 | 13 | 5-4 | 1,200 | Louisville | Ky. | duPont Manual Stadium |