13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/2011 | H | Murray State | W | 21 | 9 | 1-0 | 46,157 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/09/2011 | H | Florida International | L | 17 | 24 | 1-1 | 47,228 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/17/2011 | A | Kentucky | W | 24 | 17 | 2-1 | 68,170 | Lexington | Ky. | Commonwealth Stadium | |||||
| 10/01/2011 | H | Marshall | L | 13 | 17 | 2-2 | 53,267 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 10/08/2011 | A | North Carolina | L | 7 | 14 | 2-3 | 51,500 | Chapel Hill | N.C. | Kenan Stadium | |||||
| 10/15/2011 | A | Cincinnati | L | 16 | 25 | 2-4 | 0-1 | 40,971 | Cincinnati | Ohio | Paul Brown Stadium | ||||
| 10/21/2011 | H | Rutgers | W | 16 | 14 | 3-4 | 1-1 | 48,435 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/29/2011 | H | Syracuse | W | 27 | 10 | 4-4 | 2-1 | 44,817 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/05/2011 | A | 24 | West Virginia | W | 38 | 35 | 5-4 | 3-1 | 57,287 | Morgantown | W.Va. | Milan Puskar Stadium | |||
| 11/12/2011 | H | Pittsburgh | L | 14 | 21 | 5-5 | 3-2 | 51,321 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/19/2011 | A | Connecticut | W | 34 | 20 | 6-5 | 4-2 | 34,483 | East Hartford | Conn. | Rentschler Field | ||||
| 11/25/2011 | A | South Florida | W | 34 | 24 | 7-5 | 5-2 | 33,416 | Tampa | Fla. | Raymond James Stadium | ||||
| 12/27/2011 | N | North Carolina State | L | 24 | 31 | 7-6 | 5-2 | 58,427 | Charlotte | N.C. | Bank of America Stadium | Belk Bowl |