11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/06/1980 | H | Miami, Fla. | L | 10 | 24 | 0-1 | 22,120 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/13/1980 | A | 10 | Florida State | L | 0 | 52 | 0-2 | 52,623 | Tallahassee | Fla. | Doak Campbell Stadium | ||||
| 09/20/1980 | H | Murray State | L | 9 | 13 | 0-3 | 23,109 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/27/1980 | A | Kansas | W | 17 | 9 | 1-3 | 34,800 | Lawrence | Kan. | Memorial Stadium | |||||
| 10/11/1980 | H | Memphis | W | 38 | 14 | 2-3 | 15,501 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/18/1980 | H | Indiana State | W | 27 | 17 | 3-3 | 24,695 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/25/1980 | A | Florida | L | 0 | 13 | 3-4 | 62,687 | Gainesville | Fla. | ||||||
| 11/01/1980 | H | Temple | L | 12 | 17 | 3-5 | 13,436 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/08/1980 | A | 9 | Pittsburgh | L | 23 | 41 | 3-6 | 47,280 | Pittsburgh | Pa. | |||||
| 11/15/1980 | H | Cincinnati | W | 20 | 0 | 4-6 | 12,629 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/22/1980 | A | Southern Mississippi | W | 6 | 3 | 5-6 | 21,210 | Hattiesburg | Miss. |