11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/08/1979 | H | Virginia Tech | L | 14 | 15 | 0-1 | 29,436 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/15/1979 | A | Miami, Fla. | L | 12 | 24 | 0-2 | 41,129 | Miami | Fla. | Orange Bowl | |||||
| 09/22/1979 | H | Cincinnati | W | 22 | 19 | 1-2 | 20,174 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/29/1979 | A | Drake | W | 31 | 21 | 2-2 | 13,155 | Des Moines | Iowa | Drake Stadium | |||||
| 10/06/1979 | H | 9 | Florida State | L | 0 | 27 | 2-3 | 27,306 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 10/13/1979 | H | Tulsa | W | 24 | 7 | 3-3 | 14,941 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/20/1979 | A | Indiana State | W | 34 | 10 | 4-3 | 16,279 | Terre Haute | Ind. | Memorial Stadium | |||||
| 11/03/1979 | H | Southern Mississippi | T | 10 | 10 | 4-3-1 | 13,085 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/10/1979 | A | Memphis | L | 6 | 10 | 4-4-1 | 17,205 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||||
| 11/17/1979 | A | Maryland | L | 7 | 28 | 4-5-1 | 25,104 | College Park | Md. | Byrd Stadium | |||||
| 11/25/1979 | H | Rutgers | L | 7 | 31 | 4-6-1 | 10,152 | Louisville | Ky. | Fairgrounds Stadium |