11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/06/1986 | A | Illinois | L | 0 | 23 | 0-1 | 72,822 | Champaign | Ill. | Memorial Stadium | |||||
| 09/13/1986 | A | Indiana | L | 0 | 21 | 0-2 | 35,126 | Bloomington | Ind. | Memorial Stadium | |||||
| 09/20/1986 | H | Western Kentucky | W | 45 | 6 | 1-2 | 34,144 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/27/1986 | H | Memphis | W | 34 | 8 | 2-2 | 30,801 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/04/1986 | A | Cincinnati | L | 17 | 24 | 2-3 | 16,317 | Cincinnati | Ohio | Nippert Stadium | |||||
| 10/18/1986 | A | Boston College | L | 7 | 41 | 2-4 | 28,105 | Chestnut Hill | Mass. | Alumni Stadium | |||||
| 10/25/1986 | H | Florida State | L | 18 | 54 | 2-5 | 22,822 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/01/1986 | H | Rutgers | L | 0 | 41 | 2-6 | 20,165 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/08/1986 | A | Tulane | W | 23 | 12 | 3-6 | 22,108 | New Orleans | La. | Superdome | |||||
| 11/15/1986 | H | West Virginia | L | 19 | 42 | 3-7 | 21,834 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/22/1986 | A | Southern Mississippi | L | 16 | 31 | 3-8 | 11,231 | Hattiesburg | Miss. | M. M. Roberts Stadium |