11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/05/1987 | H | Tulane | W | 42 | 40 | 1-0 | 32,242 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/12/1987 | H | Cincinnati | L | 0 | 25 | 1-1 | 33,392 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/19/1987 | A | Purdue | T | 22 | 22 | 1-1-1 | 63,125 | West Lafayette | Ind. | Ross-Ade Stadium | |||||
| 09/26/1987 | H | Murray State | W | 34 | 10 | 2-1-1 | 29,231 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/03/1987 | H | Southern Mississippi | L | 6 | 65 | 2-2-1 | 20,647 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/10/1987 | H | Marshall | L | 31 | 34 | 2-3-1 | 21,658 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/17/1987 | A | 4 | Florida State | L | 9 | 32 | 2-4-1 | 53,114 | Tallahassee | Fla. | Doak Campbell Stadium | ||||
| 10/24/1987 | H | Akron | W | 31 | 10 | 3-4-1 | 18,743 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/31/1987 | A | Tulsa | L | 22 | 26 | 3-5-1 | 19,472 | Tulsa | Okla. | Skelly Stadium | |||||
| 11/07/1987 | A | Tennessee | L | 10 | 41 | 3-6-1 | 92,084 | Knoxville | Tenn. | Neyland Stadium | |||||
| 11/14/1987 | A | Memphis | L | 8 | 43 | 3-7-1 | 20,418 | Memphis | Tenn. | Liberty Bowl Memorial Stadium |