12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/04/1993 | H | San Jose State | W | 31 | 24 | 1-0 | 35,923 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/11/1993 | A | Memphis | W | 54 | 28 | 2-0 | 32,573 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||||
| 09/18/1993 | H | 23 | Arizona State | W | 35 | 17 | 3-0 | 39,639 | Louisville | Ky. | Cardinal Stadium | ||||
| 09/25/1993 | H | Texas | 24 | W | 41 | 10 | 4-0 | 38,492 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/02/1993 | A | Pittsburgh | 18 | W | 29 | 7 | 5-0 | 28,528 | Pittsburgh | Pa. | Pitt Stadium | ||||
| 10/09/1993 | A | 24 | West Virginia | 17 | L | 34 | 36 | 5-1 | 57,578 | Morgantown | W.Va. | Mountaineer Field | |||
| 10/16/1993 | H | Southern Mississippi | 23 | W | 35 | 27 | 6-1 | 36,322 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/23/1993 | H | Navy | 20 | W | 28 | 0 | 7-1 | 37,214 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/06/1993 | A | 7 | Tennessee | 13 | L | 10 | 45 | 7-2 | 94,826 | Knoxville | Tenn. | Neyland Stadium | |||
| 11/13/1993 | A | 11 | Texas A&M | 20 | L | 7 | 42 | 7-3 | 56,161 | College Station | Texas | Kyle Field | |||
| 11/25/1993 | A | Tulsa | W | 28 | 0 | 8-3 | 11,257 | Tulsa | Okla. | Skelly Stadium | |||||
| 12/28/1993 | N | Michigan State | 25 | W | 18 | 7 | 9-3 | 21,097 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | Liberty Bowl |