13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/2013 | H | Ohio | 9 | W | 49 | 7 | 1-0 | 55,332 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/07/2013 | H | Eastern Kentucky | 8 | W | 44 | 7 | 2-0 | 53,647 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/14/2013 | A | Kentucky | 7 | W | 27 | 13 | 3-0 | 65,445 | Lexington | Ky. | Commonwealth Stadium | ||||
| 09/21/2013 | H | Florida International | 7 | W | 72 | 0 | 4-0 | 51,586 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/05/2013 | A | Temple | 7 | W | 30 | 7 | 5-0 | 1-0 | 21,709 | Philadelphia | Pa. | Lincoln Financial Field | |||
| 10/10/2013 | H | Rutgers | 8 | W | 24 | 10 | 6-0 | 2-0 | 55,168 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/18/2013 | H | Central Florida | 8 | L | 35 | 38 | 6-1 | 2-1 | 55,215 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/26/2013 | A | South Florida | 18 | W | 34 | 3 | 7-1 | 3-1 | 35,782 | Tampa | Fla. | Raymond James Stadium | |||
| 11/08/2013 | A | Connecticut | 20 | W | 31 | 10 | 8-1 | 4-1 | 27,104 | East Hartford | Conn. | Rentschler Field | |||
| 11/16/2013 | H | Houston | 19 | W | 20 | 13 | 9-1 | 5-1 | 53,027 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/23/2013 | H | Memphis | 21 | W | 24 | 17 | 10-1 | 6-1 | 46,421 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 12/05/2013 | A | Cincinnati | 19 | W | 31 | 24 | OT | 11-1 | 7-1 | 35,097 | Cincinnati | Ohio | Nippert Stadium | ||
| 12/28/2013 | N | Miami, Fla. | 18 | W | 36 | 9 | 12-1 | 7-1 | 51,098 | Orlando | Fla. | Florida Citrus Bowl Stadium | Russell Athletic Bowl |